Prenatal screening and diagnosis
How are the fetus and the pregnant woman examined?
Clinic “Victoria” offers you “Prenatal care” Service, providing you an access to high quality prenatal care and will guide and support you through every step of this stressful and worrying moment of your life.
I trimester 11-13 week : combined test (blood test with a special kind of ultrasound)
ULTRASOUND scan allows you and your prenatal diagnosis specialist to take pictures of the embryo or fetus as it develops and determine chromosomal markers of fetal anomalies or pregnancy complications. If pregnancy term is informative to calculate risk, the blood tests can be done to determine the concentration of biochemical markers (PAPP-A and β-HCG);
- Then the calculation of individual risk of chromosomal syndromes is done by special program based on the ultrasound data of the fetus, abnormalities of biochemical markers (PAPP-A and β-HCG) and other features of the pregnant woman;
- According to the results of these calculations the pregnant is referred to the group of low (93%), medium (5%) or high (2%) risk that is noted in the conclusion of prenatal testing. If you have a high-risk pregnancy, your Prenatal diagnosis specialist may ask you to come in for prenatal care more often;
- The physician-geneticist provides a deep explanations to your results readings;
- Obtained results readings will be interpreted by the geneticist;
- The prenatal diagnosis specialist carefully evaluates prenatal indicators and if needed will offer you other tests to address your needs.
Our clinic offers a unique opportunity to provide ULTRASOUND expert examination of the fetus paired with the variance analysis of biochemical markers in the second trimester (AFP, HCG and free estriol) and calculate the risk with correction of ultrasound markers of fetal pathology. This test is undertaken between 16-18 weeks (it is permitted to be done between 15-21 weeks).
Informativity of examination of the fetus between 11-13 weeks is significantly higher than in the second trimester, so we don’t recommend you to re-calculate the risk, having a high-risk pregnancy in the first trimester, instead apply for invasive prenatal testing.
Non-invasive genetic testing (by the blood of the pregnant)
Our experts are using most innovative and advanced technologies proven by the leading scientists in their work. One of this methods is a non-invasive test (by the pregnant’s venous blood) to identify the RH factor of the fetus, trisomy of chromosomes 21, 18, 13 and sex of the fetus (Prena-test).
The test result is displayed in the form of risk and in most cases is almost well-defined: the risk of trisomy of>99% (need to confirm fetal chromosomal abnormalities using invasive procedures) or <1% (99% chance that the fetus does not have this trisomy). Results of non-invasive tests should be interpreted by the geneticist.
Who is recommended non-invasive genetic testing?
- Pregnant with RH-negative blood type in order to take measures to prevent rhesus-conflict timely, if the fetus was defined with positive RH factor.
- If there is a high risk of the disease, which is inherited by the gender.
- While detecting a high risk of Down syndrome (trisomy 21) , Edwards (trisomy 18) or Patau (trisomy 13) for women who are having difficulties to make a decision to undertake invasive prenatal diagnosis.
When is non-invasive genetic testing undertaken?
- The gene of the rhesus factor (RHD) can be identified in the blood of a pregnant starting about 12 week of pregnancy with a high probability of (99%).
- Prena-test is made from 10 week of pregnancy.
Invasive prenatal diagnosis
The specialists of the clinic “Victoria” have long standing experience providing invasive technique for prenatal diagnosis to detect birth defects and other abnormalities related to genetic issues in accordance with the recommendations of the European Cytogenetics Association.
Who is prescribed invasive prenatal?
Invasive technique can be applied during specific time periods of the pregnancy, starting at 14 weeks gestation and only if there are medical indications, regulated by the valid order of the Ministry of Health of Ukraine.
Invasive method can be employed if following tests are done:
- Blood and urine tests;
- Blood group and RH-type (if negative you need to determine RH antibodies);
- HIV, hepatitis B and C tests;
- Blood glucose;
- Urogenital smear microscopy.
The risk of complications during invasive diagnosis
Any surgical interference is always associated with the risk of complications. Risks with invasive procedures are uncommon, and proven that the complication rate depends on the proper determination of gestational age and experience of the doctor.
The longstanding experience of our specialists allows minimizing the risks. The frequency of complications after invasive diagnostics in the clinic “Victoria” is not greater than 0.05% when the efficiency is 99.6% and a detection rate of chromosomal abnormalities is 13-15%.