Preimplantation Genetic Diagnosis procedure is performed within the context of an IVF Cycle to select embryos free of chromosomal and gene abnormalities and specific genetic disorders prior to transferring to the Uterus. This unique method helps not only to select, the best embryos for transfer to the uterine cavity, but it also improves the efficiency of the treatment and reduces the potential for adverse pregnancy outcomes.



Who is recommended PGD?

  • The woman is aged 38 or older;
  • Patients with a history of recurrent miscarriage;
  • Patients with repeated IVF failure, for example 5 or more embryos have been replaced without success;
  • Couples at risk of trans-chromosomally abnormal pregnancy (Down syndrome).




How does PGD work?

PGD, preimplantation genetic diagnosis, involves removing cells from an IVF embryo to test it for a specific genetic condition (cystic fibrosis, for example) before transferring the embryo to the uterus, applying the modern genetic methods. Don’t worry – properly performed biopsy is safe for the embryo and does not affect its further development.
Obtaining material for analysis may be performed at different stages of embryo development. Thus, a single blastomere can be biopsied on the third day of culture. Then all cells of the embryo have the capacity for unlimited “regeneration” and the cells extraction is rapidly compensated by the active division of the blastomeres, which are beside. An alternative option is trophectoderm biopsy on the fifth day of embryo development, when the embryo has already formed a blastocyst. In this case, more cells can be removed from the trophectoderm, which will form the placenta in the future. Thus more cells may be biopsied without compromising the viability of the embryo, and leading to a more accurate test.
Thus, regardless of the stage of embryo development at what the biopsy was carried out, it has no capacity for damaging the developmental potential of the  embryo, and this is confirmed by the high pregnancy rates in  IVF treatment cycles where PGD procedure was performed.



Individual Protocol of the embryos genetic testing

A variety of hereditary abnormalities requires more individual approach to PGD. At the “Reproductive Genetics Clinic “Victoria” we will work over   individual   Protocol of embryo genetic testing for carriers of genetic disorders. Therefore preparing of the couple to the cycle of infertility treatment requires longer and meticulous arrangement.

For patients with confined hereditary risks PGD could be an important alternative to prenatal diagnosis. Thus if the pregnancy was achieved naturally, but the anomaly the child inherited the disease, there is a need to make difficult decision. Genetic testing of embryos on the pre-implantation stage helps to avoid this difficult dilemma, but in such case even fertile couples should undergo a cycle of IVF treatment. (hyperlink).



The wide range of genetic investigations is offered in the clinic “Victoria”. The clinic’s specialists will assist you:

  • with all information relevant  to preimplantation genetic diagnosis procedure;
  • with making informed decision in selection of a suitable individual plan of treatment.




We will be confidently going together towards the common goal – achieving the miracle of having a healthy child!

Dedicated experts


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